MICRORNAS AS ULTRAVIOLET IRRADIATION EFFECTS REGULATORS IN SKIN CELLS

MicroRNAs belong to small non-coding RNA which regulate gene expression via mRNA degradation or translation inhibition. MicroRNAs are active modulators of gene expression in the skin caused by exogenous factors including ultraviolet irradiation. These effects are realized by targeting transcription factors and signaling systems components. Changes in microRNAs levels started to register in a few hours after exposure to ultraviolet irradiation, wich confirms the presence of an effective fast processes in the scin cells that modulate the functional status of microRNAs. The reported recently ability of microRNAs to be transported by exosomes may be related to systemic effects of ultraviolet irradiation that include the altered immune response and systemic inflammatory reaction. Understanding these processes is important because of the possibility of purposeful influence on the expression and activity of a microRNA that may have implications for diagnosis and therapy of photodermatosis and malignant skin tumors.