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Related Experiment Video

Updated: Feb 5, 2026

Liver Cold Storage and Transplantation in the Cold-Adaptive Daurian Ground Squirrels
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Published on: July 3, 2025

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[BASIC PHYSIOLOGICAL MECHANISMS OF HUMAN ADAPTATION TO COLD].

M M Saltykova

    Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova
    |September 11, 2018
    PubMed
    Summary

    Human adaptation to cold involves skeletal muscle and brown adipose tissue. Key mechanisms for heat production include muscle activity and altered cellular energy processes, enhanced by mitochondria.

    Area of Science:

    • Physiology
    • Molecular Biology
    • Thermoregulation

    Background:

    • Human adaptation to cold is a complex physiological process.
    • Understanding thermogenesis mechanisms is crucial for survival in cold environments.

    Purpose of the Study:

    • To review literature on human cold adaptation.
    • To identify key mechanisms of adaptive thermogenesis.

    Main Methods:

    • Literature review of physiological and molecular studies.
    • Analysis of studies on heat production mechanisms.

    Main Results:

    • Skeletal muscle oxidative fibers and brown adipose tissue are primary contributors to adaptive thermogenesis.
    • Heat generation sources include muscle activity and uncoupling of oxidative phosphorylation.

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  • Long-term cold adaptation involves increased mitochondria number and activity.

    • Conclusions:

    • Cold adaptation relies on both skeletal muscle and brown adipose tissue.
    • Molecular mechanisms confirm and expand upon previous physiological findings.
    • Mitochondrial adaptations are key for sustained energy production in cold.