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Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
Published on: March 3, 2023
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Nasal challenges in allergen immunotherapy trials.
Mark W Tenn1,2, Matthew Rawls1,2, Anne K Ellis1,2,3
1Department of Biomedical and Molecular Sciences, Queen's University.
Current Opinion in Allergy and Clinical Immunology
|September 11, 2018
Summary
The nasal allergen challenge (NAC) model aids in diagnosing allergic rhinitis and evaluating allergen immunotherapy (AIT). Recent studies show NACs effectively assess AIT efficacy for various allergens, improving symptoms and nasal tolerance.
Area of Science:
- Allergy and Immunology
- Otorhinolaryngology
Background:
- The nasal allergen challenge (NAC) model is a key tool for diagnosing allergic rhinitis.
- NACs serve as crucial endpoints in clinical trials for allergen immunotherapy (AIT).
Purpose of the Study:
- This review details the technical aspects of the NAC model.
- It summarizes recent studies evaluating AIT treatments using NACs.
Main Methods:
- Recent studies employed titrated and single-dose NAC protocols.
- These protocols assessed immunotherapies for grass, birch, house dust mite, and cat allergens.
Main Results:
- AIT treatments demonstrated improvements in allergic symptoms and nasal tolerance.
- NACs were utilized in proof-of-concept studies for intralymphatic and subcutaneous immunotherapy.
Conclusions:
- NACs are valuable for early-stage AIT treatment evaluation.
- Standardized NAC protocols are essential for comparing study results.
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