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Outcomes for Invasive Melanomas Treated With Mohs Micrographic Surgery: A Retrospective Cohort Study
Catherine A Degesys1, Helen B Powell2, Ling-Lun B Hsia3
1Department of Dermatology, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina.
Background:
Mohs micrographic surgery (MMS) has been used effectively to treat invasive melanoma.
Objective:
To further study the safety and efficacy of MMS in the treatment of invasive melanoma.
Methods And Materials:
A retrospective cohort study evaluated 123 melanomas excised using MMS with MART-1 immunostain. Local recurrence, metastasis, overall survival, and disease-free survival rates were calculated. These were compared with historical controls.
Results:
Among included patients, 78 were men (63%) and 45 were women (37%), with a mean age of 66.48 years. Mean follow-up time was 1,273 days (3.49 years). Local recurrence was identified in 2/123 (1.63%; 95% confidence interval, 0.20%-5.75%) lesions. Local recurrence was identified in 1/70 (1.43%; 95% confidence interval, 0.04%-7.70%) of head and neck cases. Tumor location was head and neck in 70 lesions (56.9%). Overall survival was 95.12% and disease-specific survival was 100%.
Conclusion:
Mohs micrographic surgery is an effective treatment method for invasive melanoma, as evidenced by low recurrence rates and high rates of disease-free survival.
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