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The baseline levels and risk factors for high-sensitive C-reactive protein in Chinese healthy population
Ying Tang1,2, Peifen Liang1,2, Junzhe Chen1,2
11Department of Nephrology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Insights
Serum high-sensitivity C-reactive protein (hs-CRP) increases with age and is higher in males. Elevated hs-CRP is linked to higher uric acid and lower HDL cholesterol and SOD, indicating it may signal aging in healthy Chinese adults.
Area of Science:
- Biochemistry
- Gerontology
- Clinical Chemistry
Background:
- C-reactive protein (CRP) is recognized as both a biomarker and a pathogenic factor in inflammation and age-related diseases.
- Serum CRP levels in healthy aging populations are not well-established.
- This study aimed to clarify serum CRP levels in a healthy aging Chinese cohort.
Purpose of the Study:
- To investigate the relationship between serum high-sensitivity C-reactive protein (hs-CRP) levels and aging in a healthy Chinese population.
- To explore correlations between hs-CRP and other metabolic and oxidative stress markers.
- To determine if hs-CRP can serve as an indicator of aging in healthy individuals.
Main Methods:
- Serum levels of hs-CRP, glucose, triglyceride, cholesterol, HDL-c, LDL-c, SOD, SCr, and SUA were measured.
- Data were collected from 6060 healthy subjects (3672 males, 2388 females, mean age 45.9 years) undergoing routine physical examination.
- Statistical analyses were performed to assess age and sex differences and correlations.
Main Results:
- Serum hs-CRP levels significantly increased with age (P < 0.05), especially in individuals over 45 years old.
- Males exhibited significantly higher serum hs-CRP levels compared to females (P < 0.001).
- hs-CRP positively correlated with age and serum uric acid (SUA), and inversely correlated with HDL-c and superoxide dismutase (SOD) (all P < 0.05).
Conclusions:
- Baseline serum hs-CRP levels rise with aging and are higher in healthy males than females in the Chinese population.
- Elevated hs-CRP is associated with increased SUA and decreased HDL-c and SOD.
- Serum hs-CRP may serve as a potential indicator associated with aging in healthy Chinese adults.
Background:
Recent studies show that C-reactive protein (CRP) is not only a biomarker but also a pathogenic mediator contributing to the development of inflammation and ageing-related diseases. However, serum levels of CRP in the healthy ageing population remained unclear, which was investigated in the present study.
Methods:
Serum levels of high sensitive C-reactive protein (hs-CRP), glucose (Glu), triglyceride (TG), cholesterol (CHOL), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), superoxide dismutase (SOD), serum creatinine (SCr), serum uric acid (SUA) were measured in 6060healthy subjects (3672 male and 2388 female, mean age:45.9 years) who received routine physical examination at Sun Yat-sen Memorial Hospital, Guangzhou, China.
Results:
In total of 6060 healthy people, serum levels of hs-CRP were significantly increased with ageing (P < 0.05), particularly in those with age over 45-year-old (1.31[0.69-2.75] vs 1.05[0.53-2.16]mg/L, P < 0.001). Interestingly, levels of serum hs-CRP were significantly higher in male than female population (1.24[0.65-2.57] vs 1.07[0.53-2.29]mg/L, P < 0.001). Correlation analysis also revealed that serum levels of hs-CRP positively correlated with age and SUA, but inversely correlated with serum levels of HDL-c and SOD (all P < 0.05).
Conclusions:
Baseline levels of serum hs-CRP are increased with ageing and are significantly higher in male than female healthy population. In addition, elevated serum levels of hs-CRP are also associated with increased SUA but decreased HDL-c and SOD. Thus, serum levels of hs-CRP may be an indicator associated with ageing in healthy Chinese population.
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