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Updated: Feb 5, 2026

Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies
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Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies

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Engineered Cross-Linking to Study the Pore Architecture of the CRAC Channel

Guolin Ma1, Lian He1, Ji Jing1

  • 1Center for Translational Cancer Research, Institute of Biosciences and Technology, College of Medicine, Texas A&M University, 2121 W. Holcombe Blvd, Houston, TX, USA.

Methods in Molecular Biology (Clifton, N.J.)
|September 12, 2018
PubMed

Keywords:
Calcium release-activated calcium channelCalcium signalingCross-linkingDisulfide bondLymphocyte activationMembrane proteinORAI1Store-operated calcium entryStromal interaction moleculeStructure

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