[ANALYSIS OF COGNITIVE DISORDERS WITH DIFFERENT CLINICAL FORMS OF PARKINSON'S DISEASE]

The purpose of this study is to assess the dynamics of cognitive impairment in patients with Parkinson's disease during the first 2 years of the disease, to study the peculiarities of cognitive impairment in patients with Parkinson's disease with different clinical forms. The study included 54 patients, 30 men and 18 women. After a year, 51 patients were re-admitted, in 2 years - 48 patients (6 patients were not included in the end). Average age at the beginning of the study was 65.6 ±3.7 years. The duration of the disease ranged from 2 to 8 years and averaged 5.9 ±4.2 years, the mean age at the onset of the disease was 58.4±4.3 years. The digital data was processed by a variational-statistical method. Student's t-test was used. Correlation analysis is performed by the method of Spearman's rank correlation. The diagnosis was established according to the criteria developed by Hughes et al. All patients underwent CT or MRI examination. Patients in clinical forms were divided into 3 groups: I group - rigid-bradykinetic form - 13 patients; Group II - the mixed (tremor-rigid) form 24 patient; Group III - the trembling form - 11 patients. The mental sphere of the patients was studied on a psychomotor scale at the beginning of the study, after 1 and 2 years, the Blessed information-Memory-Concentration (BIMC) test was used. Studies have shown that with Parkinson's disease, along with motor impairments, mental sphere disorders occur, although not in all cases. Approximately in 25% of cases mental disorders are not detected. Clinically significant worsening of cognitive functions during 2 years is observed in 20.83% of patients. A vivid correlation between the mental deficit and clinical forms of the disease was not found (p<0.5).