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Updated: Feb 5, 2026

A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Spleen Cell Biology and Transplant Immunity
Published on: June 11, 2019
HISTOLOGICAL CHANGES IN SPLEEN UNDER CONDITIONS OF TOXIC CARCINOGENESIS
N Lisnychuk1, Yu Soroka1, I Andrijchuk1
1I. Horbachevsky Ternopil State Medical University, Central Scientific Research Laboratory; I. Horbachevsky Ternopil State Medical University, Department of Anaesthesiology and Intensive Care Medicine; I. Horbachevsky Ternopil State Medical University, Department of Histology and Embryology, Ukraine.
Abstract:
Under development of dimethylhydrazine-induced adenocarcinomatosis of the large intestine in white outbred male rats morphological changes of the structural components of the spleen were studied. It was found, that the progression of experimental carcinogenesis is accompanied by severe violations of the morphological state of all structural components of the spleen, manifested by destructively degenerative changes of the stroma, red and white pulp and significant vascular disorders. The severity of the pathomorphological changes in the spleen increases directly proportionally to the increase of the duration of the oncogenic factor impact.
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