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Antiviral Activities of Oleanolic Acid and Its Analogues

Vuyolwethu Khwaza1, Opeoluwa O Oyedeji2, Blessing A Aderibigbe3

  • 1Department of Chemistry, University of Fort Hare, Alice Campus, Alice 5700, Eastern Cape, South Africa. vuyolwethukhwaza@gmail.com.

Molecules (Basel, Switzerland)
|September 13, 2018
PubMed

Insights

Oleanolic acid (OA) and its analogues show promise as novel antiviral drugs. This review explores their potential against critical viral infections like HIV, influenza, hepatitis, and herpes.

Area of Science:

  • Natural product chemistry
  • Virology
  • Medicinal chemistry

Background:

  • Viral diseases pose a significant global health threat, causing numerous deaths worldwide.
  • Existing antiviral treatments face challenges due to drug resistance and limited efficacy.
  • Natural products, particularly triterpenoids like oleanolic acid (OA), are valuable sources for novel drug discovery.

Purpose of the Study:

  • To review the antiviral activities of oleanolic acid (OA) and its analogues.
  • To assess their potential as therapeutic agents against major viral pathogens.
  • To highlight the importance of exploring plant-derived compounds for drug development.

Main Methods:

  • Literature review of studies on oleanolic acid (OA) and its derivatives.
  • Analysis of reported antiviral activities against specific viruses.
  • Compilation of data on structure-activity relationships.

Main Results:

  • Oleanolic acid (OA) and its analogues exhibit significant antiviral properties.
  • These compounds have demonstrated activity against human immune deficiency virus (HIV), influenza, hepatitis B and C viruses, and herpes viruses.
  • Further research into OA analogues could lead to potent new antiviral drugs.

Conclusions:

  • Oleanolic acid (OA) and its analogues represent a promising class of compounds for developing new antiviral therapies.
  • Their broad-spectrum activity against various pathogenic viruses warrants continued investigation.
  • Plant-derived natural products offer a vital resource for combating the growing challenge of viral infections and drug resistance.
Keywords:
HBV/HCVHIVinfluenza virusmedicinal plantnatural producttriterpenoids

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