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Understanding drug release from PCL/gelatin electrospun blends.

Hrishikesh R Munj1, John J Lannutti2, David L Tomasko1

  • 11 Department of Chemical and Biomolecular Engineering, Ohio State University, Columbus, OH, USA.

Journal of Biomaterials Applications
|September 14, 2018
PubMed
Summary

Electrospun polycaprolactone (PCL)-gelatin scaffolds show Rhodamine B dye release primarily driven by media diffusion. Scaffold thickness and gelatin

Keywords:
CO2 impregnationPolymer blendsdiffusiondrug releaseelectrospinning

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Area of Science:

  • Biomaterials Engineering
  • Polymer Science
  • Drug Delivery Systems

Background:

  • Electrospinning is a key technique for fabricating fibrous scaffolds for biomedical uses.
  • Understanding drug release mechanisms from polymer blends is crucial for optimizing scaffold performance.
  • Polymer blends combine mechanical and bioactive properties, but drug release kinetics can be complex.

Purpose of the Study:

  • To investigate the drug release mechanism of Rhodamine B dye from electrospun polycaprolactone (PCL)-gelatin blends.
  • To evaluate the effect of high-pressure carbon dioxide on drug loading and release characteristics.
  • To elucidate the influence of scaffold thickness and gelatin content on release kinetics.

Main Methods:

  • Fabrication of electrospun PCL-gelatin blend scaffolds.
  • Incorporation of Rhodamine B dye as a model drug.
  • Analysis of drug release profiles under varying conditions, including the effect of high-pressure CO2.

Main Results:

  • Release media diffusion was identified as the dominant drug release mechanism for PCL-gelatin electrospun fibers.
  • Scaffold thickness significantly impacts drug release, particularly due to the properties of gelatin.
  • Gelatin's high water solubility and gelation tendency influence the diffusion of release media.

Conclusions:

  • Drug release from electrospun PCL-gelatin scaffolds is primarily governed by diffusion.
  • Scaffold design parameters, especially thickness and composition, critically affect drug release rates.
  • This study provides fundamental insights into the release mechanisms from electrospun polymer blends.