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Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
Published on: February 13, 2016
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Understanding drug release from PCL/gelatin electrospun blends
Hrishikesh R Munj1, John J Lannutti2, David L Tomasko1
11 Department of Chemical and Biomolecular Engineering, Ohio State University, Columbus, OH, USA.
Journal of Biomaterials Applications
|September 14, 2018
Summary
Electrospun polycaprolactone (PCL)-gelatin scaffolds show Rhodamine B dye release primarily driven by media diffusion. Scaffold thickness and gelatin
Area of Science:
- Biomaterials Engineering
- Polymer Science
- Drug Delivery Systems
Background:
- Electrospinning is a key technique for fabricating fibrous scaffolds for biomedical uses.
- Understanding drug release mechanisms from polymer blends is crucial for optimizing scaffold performance.
- Polymer blends combine mechanical and bioactive properties, but drug release kinetics can be complex.
Purpose of the Study:
- To investigate the drug release mechanism of Rhodamine B dye from electrospun polycaprolactone (PCL)-gelatin blends.
- To evaluate the effect of high-pressure carbon dioxide on drug loading and release characteristics.
- To elucidate the influence of scaffold thickness and gelatin content on release kinetics.
Main Methods:
- Fabrication of electrospun PCL-gelatin blend scaffolds.
- Incorporation of Rhodamine B dye as a model drug.
- Analysis of drug release profiles under varying conditions, including the effect of high-pressure CO2.
Main Results:
- Release media diffusion was identified as the dominant drug release mechanism for PCL-gelatin electrospun fibers.
- Scaffold thickness significantly impacts drug release, particularly due to the properties of gelatin.
- Gelatin's high water solubility and gelation tendency influence the diffusion of release media.
Conclusions:
- Drug release from electrospun PCL-gelatin scaffolds is primarily governed by diffusion.
- Scaffold design parameters, especially thickness and composition, critically affect drug release rates.
- This study provides fundamental insights into the release mechanisms from electrospun polymer blends.
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