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Updated: Feb 5, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
HDAC4 in ischemic stroke: mechanisms and therapeutic potential
Qingsheng Kong1,2, Yongnan Hao3, Xin Li4
1Collaborative Innovation Center for Birth Defect Research and Transformation of Shandong Province, Jining Medical University, 133 Hehua Road, Taibaihu New District, Jining, 272067, Shandong, China.
Abstract:
Stroke is one of the leading causes of death and disability worldwide, and the majority of the cases are ischemic stroke. However, it still lacks effective treatment except for thrombolytic therapy in an extremely narrow time window. Increased evidence suggests that histone deacetylase 4 (HDAC4) was dysregulated in ischemic stroke, which plays a key role in the pathogenesis of ischemic stroke and post-stroke recovery by affecting neuronal death, angiogenesis, and neurogenesis. Therefore, we aim to review the dysregulation of HDAC4 in ischemic stroke and the role of dysregulated HDAC4 in the pathogenesis of ischemic stroke. Furthermore, the therapeutic potential of modulating HDAC4 in ischemic stroke is discussed.
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