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Derivation of a Human Brain Organoid with Microglia Development
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Brain Organoids: Expanding Our Understanding of Human Development and Disease
L B Chuye1, A Dimitri1,2, A Desai1
1Department of Pathology and Anatomical Sciences, State University of New York, Buffalo, NY, USA.
Results and Problems in Cell Differentiation
|September 14, 2018
Summary
Stem cell-derived brain organoids model prenatal human brain development. These models, using induced pluripotent stem cells (iPSCs), are crucial for studying neurological disorders like autism and schizophrenia.
Area of Science:
- Neuroscience
- Developmental Biology
- Stem Cell Research
Background:
- Stem cell-derived brain organoids mimic prenatal human brain development.
- Induced pluripotent stem cell (iPSC) technology enables disease modeling.
Purpose of the Study:
- To review the history, development, and applications of brain organoids.
- To highlight organoid utility in modeling neurological diseases such as autism, microcephaly, and schizophrenia.
- To explore future applications integrating organoids with advanced technologies.
Main Methods:
- Review of existing literature on stem cell-derived brain organoids.
- Focus on cerebral organoids from embryonic stem cells and iPSCs.
- Discussion of organoid applications in disease modeling.
Main Results:
- Organoids provide a model for studying human brain development.
- Organoids are valuable for investigating neurological conditions like schizophrenia.
- Emerging applications combine organoids with nanophotonics, optogenomics, and atomic force microscopy.
Conclusions:
- Brain organoids represent a significant advancement in neuroscience research.
- Organoid technology holds promise for understanding and treating neurological diseases.
- Integration with new technologies will expand the capabilities of organoid models.
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