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Protein- and Peptide-Based Biosensors in Artificial Olfaction
Arménio J M Barbosa1, Ana Rita Oliveira1, Ana C A Roque1
1UCIBIO, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal.
Trends in Biotechnology
|September 15, 2018
Summary
Biological proteins like olfactory receptors (ORs) and odorant-binding proteins (OBPs) are key to animal smell. These proteins show promise for developing advanced gas biosensors and artificial olfaction systems.
Area of Science:
- Biochemistry
- Biosensor Technology
- Artificial Olfaction
Background:
- Animals use olfactory receptors (ORs) and odorant-binding proteins (OBPs) for odor detection.
- These biological molecules are increasingly utilized in gas-phase biosensor applications.
- Their interactions inspire the design of selective peptides for odorant recognition.
Purpose of the Study:
- To review the progress of gas biosensors utilizing biological sensing units.
- To highlight the use of ORs, OBPs, and peptides in detecting gas-phase analytes.
- To discuss future directions in artificial olfaction based on biological components.
Main Methods:
- Literature review of recent advancements in biological gas biosensors.
- Analysis of studies employing ORs, OBPs, and designed peptides.
- Focus on applications for detecting gas-phase analytes.
Main Results:
- Olfactory proteins (ORs, OBPs) and peptides are effective molecular recognition elements in biosensors.
- Biological components enable sensitive detection of various gas-phase substances.
- These systems offer a foundation for sophisticated artificial olfaction.
Conclusions:
- Biological units, including ORs, OBPs, and peptides, are crucial for advancing gas biosensor technology.
- Future artificial olfaction systems can benefit from insights gained from these natural olfactory components.
- Further research into biological sensing mechanisms will drive innovation in gas detection.
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