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Particle-Stabilized Fluid-Fluid Interfaces: The Impact of Core Composition on Interfacial Structure
Alison Tasker1,2, Frank Sainsbury1, Simon Puttick1,2
1Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, QLD, Australia.
Frontiers in Chemistry
|September 15, 2018
Summary
Encapsulating drugs in nanomaterials using emulsions is key for therapeutics. This review explores how core composition affects particle self-assembly at fluid interfaces for drug delivery vehicles.
Area of Science:
- Nanomaterial science
- Colloidal chemistry
- Drug delivery systems
Background:
- Nanomaterial encapsulation enhances therapeutic delivery.
- Emulsions serve as templates for synthesizing drug-loaded nanomaterials.
- Interfacial chemistry is crucial for controlling nanomaterial properties.
Purpose of the Study:
- To review encapsulation strategies using particle-stabilized emulsions.
- To focus on virus-like particles and polymer microcapsules.
- To examine how core composition influences particle self-assembly at fluid interfaces.
Main Methods:
- Review of studies on particle and protein deposition at fluid-fluid interfaces.
- Analysis of emulsion templating for nanomaterial synthesis.
- Investigation of interfacial phenomena in multi-component systems.
Main Results:
- Particle self-assembly at fluid interfaces is sensitive to core composition.
- Changes in core properties can affect particle stabilization of emulsions.
- Understanding interfacial behavior is critical for designing stable drug delivery vehicles.
Conclusions:
- Selective particle deposition on fluid interfaces is a viable encapsulation strategy.
- Virus-like particles and polymer microcapsules offer distinct advantages.
- Tailoring core composition is essential for optimizing nanomaterial-based therapeutics.
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