Copper-catalyzed synthesis of 2-aminophenyl benzothiazoles: a novel approach
S N Murthy Boddapati1, Chandra Mohan Kurmarayuni, Baby Ramana Mutchu
1Department of Chemistry, Acharya Nagarjuna University, N Nagar, Guntur, A. P-522510, India. dr.b.haribabu@gmail.com.
Abstract:
A novel, convenient and efficient protocol for the construction of various 2-aminophenyl benzothiazoles by domino intra- and intermolecular C-N cross-coupling reactions of arylisothioureas with aryl iodides using an inexpensive, air stable and readily available copper catalyst is described. The arylisothioureas were obtained from thiourea via copper promoted desulfurization followed by nucleophilic substitution. In addition, the reactivity of arylhalides and the reaction mechanism have also been studied. The protocol features operational simplicity and a broad substrate scope.
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