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Visual Acuity Outcomes in Diabetic Macular Edema With Fluocinolone Acetonide 0.2 μg/Day Versus Ranibizumab Plus
Ophthalmic Surgery, Lasers & Imaging Retina
|September 18, 2018
Summary
In pseudophakic eyes and chronic diabetic macular edema (DME), fluocinolone acetonide (FAc) showed visual outcomes comparable to ranibizumab plus deferred laser, but with significantly fewer injections. This suggests FAc as an effective treatment option for these subgroups.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Pharmacological Treatments
Background:
- Comparison of visual outcomes between the FAME study (fluocinolone acetonide [FAc]) and Protocol I (ranibizumab plus deferred laser).
- Utilized area under the curve (AUC) analysis for comparing treatment efficacy over time.
Purpose of the Study:
- To compare the visual outcomes of fluocinolone acetonide (FAc) versus ranibizumab plus deferred laser in patients with diabetic macular edema (DME).
- To evaluate treatment effects in specific subgroups, including pseudophakic eyes and those with chronic DME.
Main Methods:
- Analysis of best-corrected visual acuity (BCVA) data over 3 years of follow-up.
- Calculation of AUC for the change in BCVA over time for both treatment groups.
Main Results:
- Overall, ranibizumab plus deferred laser demonstrated a greater treatment effect than FAc.
- In subgroups of pseudophakic eyes and chronic DME, FAc showed comparable visual outcomes to ranibizumab plus deferred laser.
- The ranibizumab group received a median of 14 injections, while the FAc group received a mean of 1.3 injections over 36 months.
Conclusions:
- Fluocinolone acetonide (FAc) is a viable alternative to ranibizumab plus deferred laser for pseudophakic eyes and chronic DME subgroups.
- FAc requires significantly fewer injections compared to ranibizumab, potentially reducing treatment burden and associated risks.
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