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Updated: Feb 5, 2026

A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure
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Traumatic Stress Epigenetics.

John R Pfeiffer1,2, Leon Mutesa3, Monica Uddin1,2,4

  • 1Department of Psychology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

Current Behavioral Neuroscience Reports
|September 19, 2018
PubMed
Summary
This summary is machine-generated.

Epigenetic changes in genes related to the nervous, endocrine, and immune systems are linked to traumatic stress. Research is exploring how these epigenetic marks affect individuals and future generations.

Keywords:
DNA methylationHumanNeuroimagingPeripheral tissueTransgenerational

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Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Traumatic stress significantly impacts life domains.
  • Mechanisms of risk and resilience for stress-related psychopathologies are under investigation.
  • Epigenetics offers insights into these mechanisms.

Purpose of the Study:

  • To review recent developments in human traumatic stress epigenetics.
  • To highlight epigenetic dysregulation in response to trauma.
  • To discuss implications for understanding psychopathology.

Main Methods:

  • Review of current scientific literature on traumatic stress and epigenetics.
  • Analysis of studies examining epigenetic modifications in neural, endocrine, and immune systems.
  • Inclusion of research on imaging-epigenetic correlations and transgenerational effects.

Main Results:

  • Traumatic stress is associated with epigenetic dysregulation in key biological systems.
  • Combined imaging and epigenetic studies show promise in linking central and peripheral stress effects.
  • Evidence suggests transgenerational epigenetic effects of prenatal stress exposure.

Conclusions:

  • Focusing on central nervous system epigenetic marks is crucial for understanding peripheral measures.
  • Utilizing PTSD brain banks and multigenerational cohort data will clarify transgenerational effects.
  • Prospective, longitudinal studies are needed to advance the field.