Related Experiment Video
Updated: Feb 5, 2026

06:47
Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
Published on: September 27, 2017
10.2K
Contact Dermatitis in Atopic Dermatitis Children-Past, Present, and Future
Jenna Borok1, Catalina Matiz2, Alina Goldenberg3
1The Mount Sinai Hospital, New York, NY, 10029, USA.
Clinical Reviews in Allergy & Immunology
|September 19, 2018
Summary
Allergic contact dermatitis (ACD) is increasingly diagnosed in children. Patch testing is a safe and effective diagnostic tool for pediatric ACD, especially for those with atopic dermatitis (AD).
Area of Science:
- Pediatric Dermatology
- Allergology
- Immunology
Background:
- Allergic contact dermatitis (ACD) was once rare in children but now affects millions, prompting increased research.
- Atopic dermatitis (AD) patients show similar allergen sensitization rates to ACD patients, potentially influenced by an inflammatory (IL-4) environment.
Purpose of the Study:
- To highlight the rising incidence of pediatric allergic contact dermatitis.
- To emphasize the safety and efficacy of patch testing in diagnosing ACD in children.
- To outline key considerations for patch testing assessment in pediatric cases.
Main Methods:
- Review of current research on pediatric allergic contact dermatitis.
- Analysis of patch testing safety and effectiveness in children.
- Identification of specific clinical scenarios warranting patch testing in pediatric patients.
Main Results:
- Patch testing is confirmed as safe and effective for diagnosing ACD in children.
- Children with atopic dermatitis (AD) exhibit comparable sensitization rates to ACD patients.
- Specific clinical indicators and patient profiles necessitate careful patch testing evaluation in pediatric ACD.
Conclusions:
- Pediatric allergic contact dermatitis (ACD) is a growing concern requiring accurate diagnostic methods.
- Patch testing is a valuable tool for identifying allergens in children with ACD, including those with atopic dermatitis (AD).
- Established guidelines aid in the appropriate application and interpretation of patch testing in complex pediatric cases.
Related Concept Videos
Contact Angle
20.6K
When a solid is dipped inside a liquid, the liquid surface becomes curved near the contact. For some solid–liquid interfaces, the liquid is pulled up along the solid, while for others, the liquid surface is convex or depressed near the solid surface. This phenomenon can be explained using the concept of cohesive and adhesive forces.
The adhesive force is the molecular force between molecules of different materials, that is, between the molecules of the solid and the liquid. The cohesive...
The adhesive force is the molecular force between molecules of different materials, that is, between the molecules of the solid and the liquid. The cohesive...
20.6K
Contact-dependent Signaling
47.5K
Contact-dependent signaling, as the name suggests, requires that communicating cells be in direct contact with each other. This is achieved either through receptor-ligand interactions or by specialized cytoplasmic channels that allow the flow of small molecules between cells. In animal cells, channels called gap junctions facilitate contact-dependent signaling in certain tissues, whereas, plasmodesmata perform a similar function in plants.
Gap Junctions
In animal cells, gap junctions are formed...
Gap Junctions
In animal cells, gap junctions are formed...
47.5K
Drug Dosing: Infants and Children
302
Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
302
Transmission-based Precautions I: Contact, Enteric, and Droplets
4.6K
Transmission-based precautions are for patients known to be infected or suspected to be infected or colonized with organisms that pose a significant risk to others. Some transmission-based precautions include contact, enteric, and droplet.
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
4.6K
Pedigree Analysis
89.5K
Overview
89.5K
Nature and Nurture
22.4K
Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
22.4K

