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Role of ghrelin in pancreatic development and function.
Tiziana Napolitano1,2, Serena Silvano1,2, Andhira Vieira1,2
1Inserm, CNRS, iBV, University of Nice Sophia Antipolis, Nice, France.
Diabetes, Obesity & Metabolism
|September 20, 2018
Summary
Ghrelin, a gastric hormone, influences growth hormone secretion and appetite. This review explores its complex role in pancreatic function and glucose homeostasis, particularly concerning type II diabetes and obesity.
Area of Science:
- Endocrinology
- Metabolic Research
- Physiology
Background:
- Ghrelin is a gastric peptide with anabolic functions.
- It stimulates growth hormone (GH) secretion and modulates hypothalamic circuits controlling food intake and energy expenditure.
- Ghrelin also plays a role in pancreatic development and physiology.
Purpose of the Study:
- To review the intricate relationship between ghrelin, the pancreas, and glucose homeostasis.
- To elucidate the not fully understood interplay between these factors.
- To highlight ghrelin's relevance in type II diabetes and obesity research.
Main Methods:
- Literature review of experimental and physiological studies.
- Analysis of ghrelin's effects on pancreatic beta-cell viability and proliferation.
- Evaluation of ghrelin's inhibitory effects on pancreatic acinar and endocrine secretory functions.
Main Results:
- Ghrelin sustains pancreatic beta-cell viability and proliferation.
- Ghrelin appears to inhibit pancreatic acinar and endocrine secretory functions.
- Ghrelin's pleiotropic activity impacts energy metabolism.
Conclusions:
- Ghrelin has a complex, multifaceted role in pancreatic physiology and glucose regulation.
- Understanding ghrelin's actions is crucial for developing new therapeutic strategies for type II diabetes and obesity.
- Further research is needed to fully comprehend the ghrelin-pancreas-glucose homeostasis axis.
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