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Updated: Feb 5, 2026

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Published on: November 22, 2024
Recombinant Human Platelet-Derived Growth Factor-BB in Human Alveolar Ridge Augmentation: A Review of the Literature
Purpose:
The objective of this study was to review the available literature regarding the use of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) in human alveolar ridge augmentation and to assess its effectiveness for this specific use.
Materials And Methods:
Three electronic searches of the MEDLINE database were performed.
Results:
This review noted a wide range of study protocols, carrier systems, study periods, and outcome measures.
Conclusion:
Within the limits of this literature review, the use of rhPDGF-BB and bone regeneration/ridge augmentation led to greater clinical attachment level gain and bone regeneration prior to implant placement. More controlled clinical studies are needed to establish the effectiveness of rhPDGF-BB in alveolar ridge augmentation.
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