Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Temporal comparisons in bacterial chemotaxis.

J E Segall, S M Block, H C Berg

    Proceedings of the National Academy of Sciences of the United States of America
    |December 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Beta-Decay Half-Lives beyond ^{54}Ca: A Systematic Survey of Decay Properties Approaching the Neutron Dripline.

    Physical review letters·2026
    Same author

    Constraining the Synthesis of the Lightest p Nucleus ^{74}Se.

    Physical review letters·2025
    Same author

    Universal Effective Charges in the sd and fp Shells.

    Physical review letters·2025
    Same author

    First Study of the ^{139}Ba(n,γ)^{140}Ba Reaction to Constrain the Conditions for the Astrophysical i Process.

    Physical review letters·2024
    Same author

    Proton Shell Gaps in N=28 Nuclei from the First Complete Spectroscopy Study with FRIB Decay Station Initiator.

    Physical review letters·2024
    Same author

    Comprehensive Test of the Brink-Axel Hypothesis in the Energy Region of the Pygmy Dipole Resonance.

    Physical review letters·2021
    Same journal

    Chemotactic self-organization captures the dynamics of mammalian hair follicle patterning.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Tomographic imaging of superconducting order using particle-hole interference.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Inhibitory potential of autologous neutralizing antibodies sets quantitative limits on the rebound-competent HIV-1 reservoir.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Inferring epidemiological parameters under an infectious phylogeography model with visitor dynamics.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Analytical modeling for suction cup designs for skin-interfaced wearable devices.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Improving cell-free metabolism through direct integration of artificial respiratory chains.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    See all related articles

    Escherichia coli cells compare past stimuli to navigate. Wild-type cells weigh recent past positively and older past negatively, while mutants show altered temporal comparison abilities.

    Area of Science:

    • Microbiology
    • Cellular Biology
    • Biophysics

    Background:

    • Bacterial chemotaxis is crucial for survival, enabling cells to sense and respond to chemical gradients.
    • Understanding the temporal dynamics of chemotaxis reveals how bacteria process information over time.
    • Previous studies suggest a temporal integration window, but its precise nature and limitations are debated.

    Purpose of the Study:

    • To investigate the temporal comparison mechanisms in Escherichia coli chemotaxis.
    • To characterize the temporal weighting functions of wild-type and mutant strains.
    • To determine the role of specific genes (cheR, cheB, cheZ) in temporal signal processing.

    Main Methods:

    • Stimulation of tethered Escherichia coli cells with various temporal stimuli (impulse, step, exponential-ramp, sine-wave).

    Related Experiment Videos

  • Analysis of cellular responses, accounting for nonlinear threshold effects.
  • Characterization of mutant responses (cheRcheB, cheZ) to assess temporal processing deficits.

    • Main Results:

    • Wild-type cells exhibit short-term temporal comparisons, weighting the past second positively and the preceding 3 seconds negatively.
    • cheRcheB mutants fail to perform short-term temporal comparisons and show impaired adaptation.
    • cheZ mutants demonstrate significantly extended temporal weighting, extending at least 40 seconds into the past.
    • The chemotaxis system exhibits high gain, with single receptor occupancy changes eliciting substantial responses.

    Conclusions:

    • Escherichia coli employs a sophisticated temporal comparison strategy for chemotaxis, integrating past stimuli over a defined window.
    • Specific genes, like cheR, cheB, and cheZ, play critical roles in modulating the temporal dynamics and adaptation capabilities of the chemotactic system.
    • The findings provide a quantitative model for bacterial temporal information processing and highlight the system's sensitivity.