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Updated: Feb 4, 2026

Synthesis and Catalytic Performance of Gold Intercalated in the Walls of Mesoporous Silica
Published on: July 9, 2015
Mesoporous Silica-Based Nanoparticles for Light-Actuated Biomedical Applications via Near-Infrared Two-Photon
Jonas G Croissant1, Jean-Olivier Durand2
1Chemical and Biological Engineering, University of New Mexico, Albuquerque, NM, United States; Center for Micro-Engineered Materials, Advanced Materials Laboratory, University of New Mexico, Albuquerque, NM, United States.
Abstract:
In this review, we highlight the design of nanomaterials for two-photon excitation, in order to treat tumors with a high accuracy. Indeed two-photon excitation allows remote control of the nanoparticles with a spatio-temporal resolution. The nanomaterials are based on mesoporous silica-organosilica nanoparticles including core-shell systems. The therapeutic treatments include drug delivery, photodynamic therapy, gene silencing, and their combinations. At first, the nanosystems designed for two-photon-triggered cytotoxic drug delivery are reviewed. Then the nanomaterials prepared for two-photon photodynamic therapy and reactive oxygen species delivery are discussed. Finally, the nanosystems combining drug delivery or gene silencing with two-photon photodynamic therapy are presented. Due to the rapid progresses concerning two-photon-excited nanomaterials and the interest of near-infrared light to treat deep tumors, we believe this technology could be of high interest for the personalized medicine of the future.
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