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Updated: Feb 4, 2026

Single-cell Microinjection for Cell Communication Analysis
Published on: February 26, 2017
Insidious communication amongst cancer cells
Jeffrey J Rodvold1, Maurizio Zanetti1
1The Laboratory of Immunology, Department of Medicine and Moores Cancer Center, University of California at San Diego, La Jolla, CA, USA.
Abstract:
The tumor microenvironment is home to various types of cognate and non-cognate cell interactions. Here we comment on a newly discovered form of intercellular communication, which is based on endoplasmic reticulum stress signaling. Through this mechanism transmitter cancer cells impart receiver cancer cells with resistance to secondary metabolic, pharmacologic and genotoxic stress, providing survival advantage. The implications of this finding are briefly discussed.
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