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Updated: Feb 4, 2026

Light/dark Transition Test for Mice
Published on: November 13, 2006
One gene to rule them all…and in the darkness bind them
Konstantinos V Floros1, Anthony C Faber1
1Philips Institute for Oral Health Research, VCU School of Dentistry and Massey Cancer Center, Department of Oral and Craniofacial Molecular Biology, Virginia Commonwealth University, Richmond, VA, USA.
Abstract:
Pharmaceutical inhibition of the Human Epidermal growth factor Receptor 2 (HER2) oncogene has dramatically improved outcomes in HER2-amplified breast cancers. However, monotherapy HER2 inhibitors are not effective. We have recently reported that a co-amplified microRNA within the HER2 amplicon, leads to activation of the oncogene Myeloid Cell Leukemia-1 (MCL-1), tempering cell death responses to HER2 inhibitors. Importantly, HER2 inhibitors are sensitized to cell death by the addition of pharmacological MCL-1 inhibitors, which are entering clinical trials.
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