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Tat-HA-NR2B9c attenuate oxaliplatin-induced neuropathic pain

Hai-Hui Zhou1, Li Zhang2, Hai-Xia Zhang1

  • 1Division of Clinical Pharmacy, Department of Pharmacy, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu, China.

Experimental Neurology
|September 26, 2018
PubMed

Insights

A novel polypeptide, Tat-HA-NR2B9c, effectively treats chemotherapy-induced neuropathic pain by disrupting specific receptor interactions. This potential therapy offers pain relief without significant side effects or impacting cancer treatment.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Oncology

Background:

  • Oxaliplatin chemotherapy can cause debilitating neuropathic pain.
  • Current treatments for oxaliplatin-induced neuropathic pain are limited.
  • N-methyl-d-aspartate receptors (NMDARs) are involved in pain signaling but direct inhibition causes side effects.

Purpose of the Study:

  • To investigate the efficacy of Tat-HA-NR2B9c in treating oxaliplatin-induced neuropathic pain.
  • To determine if Tat-HA-NR2B9c can disrupt the NMDARs-PSD-95 interaction.
  • To assess the safety and specificity of Tat-HA-NR2B9c.

Main Methods:

  • Established a rat model of oxaliplatin-induced neuropathic pain.
  • Administered Tat-HA-NR2B9c to assess its analgesic effects.
  • Evaluated effects on NMDARs-PSD-95 interaction, pain behaviors, and general activity.

Main Results:

  • Oxaliplatin treatment increased the interaction between NMDARs and PSD-95.
  • Tat-HA-NR2B9c significantly reduced cold hyperalgesia and mechanical allodynia.
  • The treatment did not impair general behaviors or the antitumor activity of oxaliplatin.

Conclusions:

  • Tat-HA-NR2B9c effectively alleviates oxaliplatin-induced neuropathic pain.
  • Disrupting the NMDARs-PSD-95 complex offers a targeted pain management strategy.
  • Tat-HA-NR2B9c shows promise as a safe and effective therapeutic agent for chemotherapy-induced neuropathic pain.
Keywords:
NMDAROxaliplatinPSD95Pain

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