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Related Concept Videos

Aneurysm I: Introduction01:30

Aneurysm I: Introduction

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An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
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Aneurysm IV: Nursing Management01:22

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Vigilant monitoring for aneurysm rupture is essential for patients undergoing aortic surgery.Preoperative Nursing ManagementContinuously monitor the patient for manifestations of aneurysm rupture, such as pallor, weakness, tachycardia, hypotension, abdominal, back, groin, or periumbilical pain, changes in consciousness, and a pulsating abdominal mass. Regularly assess the patient's peripheral pulses.Instruct the patient to consume a clear liquid diet the day before surgery and administer...
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Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

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Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
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Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

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357
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
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Gene Flow02:39

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Gene flow is the transfer of genes among populations, resulting from either the dispersal of gametes or from the migration of individuals.
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Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
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The ITS2 Database
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AGD: Aneurysm Gene Database.

Ruya Sun1, Chunmei Cui1, Yuan Zhou1

  • 1Department of Biomedical Informatics, Department of Physiology and Pathophysiology, Center for Noncoding RNA Medicine, MOE Key Lab of Cardiovascular Sciences, School of Basic Medical Sciences, Peking University, Beijing, China.

Database : the Journal of Biological Databases and Curation
|September 27, 2018
PubMed
Summary
This summary is machine-generated.

A new Aneurysm Gene Database (AGD) aids research by compiling 1472 gene associations across 29 aneurysm types. This resource aims to improve aneurysm understanding and identify new therapeutic targets.

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Area of Science:

  • Cardiovascular Biology
  • Bioinformatics
  • Genomics

Background:

  • Aneurysms represent a growing public health concern, particularly with an aging global population.
  • Current therapeutic options for aneurysms are limited, and the condition is often associated with poor prognosis due to rupture and recurrence.
  • The absence of a centralized bioinformatics resource for aneurysm-associated molecules hinders research and therapeutic development.

Purpose of the Study:

  • To develop a comprehensive bioinformatics database for aneurysm-associated molecules.
  • To facilitate research into the genetic underpinnings of aneurysms.
  • To support the discovery of novel diagnostic and therapeutic targets for aneurysms.

Main Methods:

  • Development of the Aneurysm Gene Database (AGD).
  • Curated collection of aneurysm-gene associations.
  • Inclusion of diverse molecular data types, including protein-coding genes, miRNAs, and lncRNAs.

Main Results:

  • AGD integrates 1472 aneurysm-gene associations.
  • The database encompasses 29 distinct types of aneurysms.
  • It includes data on 967 protein-coding genes, 29 miRNAs, 6 lncRNAs, and other molecules.
  • AGD provides functionalities for searching, browsing, and downloading data.

Conclusions:

  • AGD serves as a valuable resource for the scientific community studying aneurysms.
  • The database can enhance the understanding of aneurysm pathogenesis.
  • AGD has the potential to accelerate the identification of novel therapeutic targets for aneurysm treatment.