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Updated: Feb 4, 2026

Gold Nanoparticle Synthesis
Published on: July 10, 2021
Gold(i)-catalysed high-yielding synthesis of indenes by direct Csp-H bond activation
Pradip D Nahide1, J Oscar C Jiménez-Halla, Katarzyna Wrobel
1Universidad de Guanajuato, Departamento de Química, División de Ciencias Naturales y Exactas, Campus Guanajuato. Cerro de la Venada S/N, 36040, Guanajuato, Gto., Mexico. csolorio@ugto.mx.
Abstract:
A catalytic, practical and high-yielding procedure for the synthesis of indenes by direct Csp3-H activation under gold(i) catalysis was developed. The scope of the protocol was determined by synthesizing some electron-neutral, electron-poor as well as electron-rich derivatives including the dibenzofurane and carbazole heterocycles. The mechanism of this reaction was elucidated by theoretical calculations using a ONIOM(M08-HX/mixed-basis:PM6) hybrid scheme. Thereby we found a pericyclic transformation involving a [1,5]-H shift generating a gold(i)-carbene that evolves to the indene derivative. In comparison with several reports, our protocol presents a direct activation of the Csp3-H bond.
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