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Related Experiment Video

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Synthesis of Near-Infrared Emitting Gold Nanoclusters for Biological Applications
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Biomedical Applications for Gold Nanoclusters: Recent Developments and Future Perspectives.

Navdeep Kaur1, Robby Nur Aditya2, Arshdeep Singh1

  • 1School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, 11031, Taiwan.

Nanoscale Research Letters
|September 28, 2018
PubMed
Summary
This summary is machine-generated.

Gold nanoclusters (AuNCs) offer unique properties for biomedical imaging, detection, and therapy. This review highlights their development, applications, and future potential as fluorescent probes.

Keywords:
BiomacromoleculesDetectionGold nanoclustersImagingPolymersSmall moleculesTherapy; ligand

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Area of Science:

  • Nanotechnology
  • Biomedical Engineering
  • Materials Science

Background:

  • Gold nanoclusters (AuNCs) possess unique chemical and physical properties making them suitable for biomedical applications.
  • Their high biocompatibility, photostability, and water solubility are advantageous for advanced medical uses.
  • Recent advancements focus on developing AuNCs as fluorescent probes for diverse biomedical applications.

Purpose of the Study:

  • To review fluorescent gold nanoclusters (AuNCs) prepared using various ligands.
  • To highlight current achievements of AuNCs in biomedical imaging, detection, and therapy.
  • To discuss challenges and future perspectives for AuNCs in biomedical fields.

Main Methods:

  • Literature review of fluorescent AuNCs synthesis and applications.
  • Categorization of AuNCs based on ligand types (small molecules, polymers, biomacromolecules).
  • Analysis of reported biomedical applications in imaging, detection, and therapy.

Main Results:

  • Fluorescent AuNCs demonstrate significant potential in long-term imaging, high-sensitivity detection, and targeted therapy.
  • Various ligands enable tailored properties for specific biomedical tasks.
  • Collected data showcases remarkable achievements in diverse medical applications.

Conclusions:

  • Gold nanoclusters are versatile fluorescent probes with substantial biomedical utility.
  • Further research is needed to address current challenges and unlock full practical potential.
  • Future directions include fundamental investigations and expanded clinical applications.