Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blind Procedures02:07

Blind Procedures

13.5K
Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which...
13.5K
Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs01:15

Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs

209
Body:Bioequivalence experimental study designs play a pivotal role in testing the effectiveness of various treatments. Key among these are the repeated measures, cross-over, carry-over, and Latin square designs. In the repeated measures design, each subject receives all treatments, allowing for temporal comparisons. This type of design is useful in reducing variability but requires careful planning to avoid bias.The cross-over design, an economical method, involves sequential administration of...
209
Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs01:20

Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs

250
Body:Bioequivalence experimental study designs are crucial methodologies used in evaluating and comparing the bioavailability of different drug products. These designs are categorized into various types: completely randomized, randomized block, repeated measures, cross and carry-over, and Latin square designs.Completely randomized designs involve randomly allocating treatments to all subjects participating in the experiment. This allocation is achieved by assigning unique random numbers to...
250
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

571
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
571
Varicose Veins II: Diagnostic Studies and Interprofessional Care01:26

Varicose Veins II: Diagnostic Studies and Interprofessional Care

222
Varicose veins, or varicosities, develop when the valves in the veins, which control blood flow, weaken or damage. It causes blood to pool and the veins to enlarge. Understanding the clinical manifestations, diagnostic approaches, and management options for varicose veins is crucial for effective treatment and relief.Clinical manifestationsClinical manifestations of varicose veins include a heavy, achy feeling or pain after prolonged standing or sitting. This discomfort can often be relieved by...
222
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

456
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
456

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reducing tokenism in patient and public involvement by integrating the Gothenburg person-centred care framework, relational bridges and impact log - a co-produced position paper.

Research involvement and engagement·2026
Same author

Translating the Living with Medicines Questionnaire from English to Swedish: a validation study.

Scandinavian journal of public health·2026
Same author

Experiences of a remote, person-centred intervention in older persons living with frailty - a qualitative study.

BMC geriatrics·2025
Same author

Economic evaluation of a person-centred care intervention with a digital platform and structured telephone support for people with chronic heart failure and/or chronic obstructive pulmonary disease: results from a randomised controlled trial in Sweden.

BMJ open·2025
Same author

Patient and healthcare professional engagement and time use within a randomised controlled trial: investigating intervention costs associated with remote person-centred care in Sweden.

BMJ open·2025
Same author

Person-Centred Care: State-of-the-Art and Future Perspectives.

Current heart failure reports·2025

Related Experiment Video

Updated: Feb 4, 2026

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies
10:38

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies

Published on: January 16, 2019

20.9K

The Precision HYpertenSIon Care (PHYSIC) study: a double-blind, randomized, repeated cross-over study.

Johan Sundström1,2, Lars Lind1, Shamim Nowrouzi1

  • 1a Department of Medical Sciences , Uppsala University , Uppsala , Sweden.

Upsala Journal of Medical Sciences
|September 29, 2018
PubMed
Summary

High blood pressure treatment varies significantly between individuals. The PHYSIC study explores personalized medicine for hypertension, aiming to improve patient adherence by matching drug responses and side effects to individual patient profiles.

Keywords:
Hypertension; blood pressure; randomised clinical trial; precision medicine

More Related Videos

A Method to Study Adaptation to Left-Right Reversed Audition
07:14

A Method to Study Adaptation to Left-Right Reversed Audition

Published on: October 29, 2018

6.9K
Double Labeling Immunofluorescence using Antibodies from the Same Species to Study Host-Pathogen Interactions
07:35

Double Labeling Immunofluorescence using Antibodies from the Same Species to Study Host-Pathogen Interactions

Published on: July 10, 2021

7.7K

Related Experiment Videos

Last Updated: Feb 4, 2026

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies
10:38

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies

Published on: January 16, 2019

20.9K
A Method to Study Adaptation to Left-Right Reversed Audition
07:14

A Method to Study Adaptation to Left-Right Reversed Audition

Published on: October 29, 2018

6.9K
Double Labeling Immunofluorescence using Antibodies from the Same Species to Study Host-Pathogen Interactions
07:35

Double Labeling Immunofluorescence using Antibodies from the Same Species to Study Host-Pathogen Interactions

Published on: July 10, 2021

7.7K

Area of Science:

  • Cardiovascular Medicine
  • Pharmacogenomics
  • Clinical Trial Design

Background:

  • Hypertension is a leading cause of premature death and societal cost globally.
  • Low patient adherence to blood pressure-lowering medications, often due to side effects, hinders effective management.
  • Precision medicine approaches are needed to tailor treatments and improve adherence.

Purpose of the Study:

  • To investigate consistent between-person variations in blood pressure response to common antihypertensive drug classes.
  • To assess between-person variations in drug-induced side effects.
  • To explore predictors and biomarkers for personalized hypertension care, aiming to maximize treatment adherence.

Main Methods:

  • A double-blind, randomized, repeated cross-over trial involving 300 patients with mild hypertension.
  • Patients received monotherapy with four drug classes: candesartan, lisinopril, amlodipine, and hydrochlorothiazide.
  • Two drug classes were repeated within each patient to assess within-person variability and between-person differences.

Main Results:

  • The study is designed to identify significant patient-specific variations in blood pressure response to antihypertensive medications.
  • It will also characterize individual differences in the occurrence and severity of side effects.
  • Findings will inform the potential for precision hypertension care by identifying response predictors.

Conclusions:

  • The PHYSIC study protocol is pre-registered (NCT02774460) and designed to evaluate personalized treatment strategies for hypertension.
  • Results may lead to a biomarker panel to guide the selection of antihypertensive drugs for individual patients.
  • The ultimate goal is to enhance patient adherence and optimize blood pressure control through precision medicine.