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Related Experiment Video

Updated: Feb 4, 2026

Analysis of Volatile and Oxidation Sensitive Compounds Using a Cold Inlet System and Electron Impact Mass Spectrometry
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[IMPACT OF PLACENTA EXTRACT ON REGENERATION OF SKIN AFTER COLD TRAUMA].

G A Kovalev, I O Ishchenko, L N Tynynyka

    Klinichna Khirurhiia
    |September 29, 2018
    PubMed
    Summary

    Placenta extract effectively reduced inflammatory markers in animal models simulating cold trauma. Key indicators like C-reactive protein and erythrocyte sedimentation rate normalized, demonstrating a significant anti-inflammatory effect.

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    Area of Science:

    • Biomedical research
    • Inflammation studies
    • Animal models

    Background:

    • Cold trauma can induce significant systemic inflammatory responses.
    • Understanding and mitigating these responses is crucial for therapeutic development.
    • Placenta extract has been investigated for potential therapeutic properties.

    Purpose of the Study:

    • To evaluate the effect of placenta extract on systemic inflammatory reactions induced by simulated cold trauma in animals.
    • To assess specific inflammatory markers including C-reactive protein, thiobarbituric acid reactive products, erythrocyte sedimentation rate (ESR), and leukocyte blood formula (LBF).

    Main Methods:

    • Simulated cold trauma was induced in an animal model.
    • Animals were treated with placenta extract.
    • Key inflammatory markers in blood serum were measured at various time points (7, 14, 21 days).

    Main Results:

    • A significant reduction in C-reactive protein levels (1.3 times) was observed by day 14.
    • Erythrocyte sedimentation rate (ESR) decreased by 1.6 times on days 7 and 14.
    • Leukocyte blood formula (LBF) normalized by day 7.
    • Active products of thiobarbituric acid levels decreased by 1.3 times on days 7, 9, and 14.
    • All measured indices returned to normal levels by day 21.

    Conclusions:

    • Placenta extract demonstrates potent anti-inflammatory effects in an animal model of cold trauma.
    • The extract effectively modulates key systemic inflammatory markers.
    • These findings suggest placenta extract as a potential therapeutic agent for inflammatory conditions.