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G A Коvalev, I O Ishchenko, O V Naumova

    Klinichna Khirurhiia
    |November 28, 2018
    PubMed
    Summary
    This summary is machine-generated.

    Biologically active substances from fetoplacental sources, including placental extract (PE) and cryopreserved cord blood serum (CPSCB), significantly enhance wound healing. CPSCB demonstrated a more potent therapeutic effect than PE.

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    Area of Science:

    • Regenerative Medicine
    • Wound Healing Research
    • Biotechnology

    Background:

    • Wound healing is a complex biological process crucial for tissue repair.
    • Fetoplacental preparations contain biologically active substances (BAS) with therapeutic potential.
    • Systemic therapy for wounds often seeks novel agents to improve healing outcomes.

    Purpose of the Study:

    • To analyze the application of fetoplacental preparations in systemic wound therapy.
    • To compare the efficacy of placental extract (PE) and cryopreserved serum of the cord blood (CPSCB) in wound healing.
    • To evaluate the impact of these preparations on wound morphology and healing processes.

    Main Methods:

    • Comparative analysis of morphological characteristics of cold wounds treated with PE and CPSCB.

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  • Assessment of tissue microcirculation, local immune responses, granulation tissue formation, and epithelialization.
  • Evaluation of the therapeutic effects of fetoplacental-derived biologically active substances.

    • Main Results:

    • Both PE and CPSCB demonstrated a stimulating impact on wound healing.
    • Improvements were observed in microcirculation, local immune processes, granulation tissue, and epithelialization.
    • Cryopreserved serum of the cord blood (CPSCB) exhibited a more significant therapeutic effect compared to PE.

    Conclusions:

    • Biologically active substances of fetoplacental origin show promise in wound treatment.
    • CPSCB is a highly effective agent for enhancing wound healing.
    • These findings support the integration of fetoplacental-derived BAS into complex wound management strategies.