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V I Tsymbalyuk, V V Medvedyev, N Ya Grydina

    Klinichna Khirurhiia
    |November 28, 2018
    PubMed
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    [IMPACT OF XENOTRANSPLANTATION OF NEUROGENIC STEM CELLS IN COMPLEX WITH THE TISSUE MATRIX NEUROGELTM ON RESTORATION OF MOTOR FUNCTION OF A RAT SPINAL CORD AFTER EXPERIMENTAL SPINAL TRAUMA].

    Klinichna khirurhiia·2018
    Same author

    [THE IMPACT OF XENOTRANSPLANTATION OF NEUROGENIC STEM CELLS IN COMPLEX WITH THE TISSUE MATRIX NEUROGELTM ON THE POSTTRAUMATIC SPASTICITY SYNDROME COURSE IN EXPERIMENT].

    Klinichna khirurhiia·2018
    Same author

    [[Durable persistence of a biocompatible foreign body in a vertebral channel in open penetrating trauma of a spinal cord: clinico-experimental and pathomorphological peculiarities].]

    Klinichna khirurhiia·2017
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    Klinichna khirurhiia·2018
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    Posttraumatic spasticity syndrome, a component of spinal cord (SC) trauma, was studied in rats. Reducing SC compression by a foreign body improved function and reduced spasticity.

    Area of Science:

    • Neuroscience
    • Regenerative Medicine
    • Spinal Cord Injury Research

    Background:

    • Posttraumatic spasticity is a debilitating component of spinal cord (SC) trauma.
    • Understanding the dynamics of spasticity is crucial for developing effective treatments.
    • Simulating SC trauma with foreign body compression offers a model to study spasticity development.

    Purpose of the Study:

    • To investigate the dynamics of posttraumatic spasticity syndrome following simulated SC trauma.
    • To determine the effect of foreign body compression on SC injury and spasticity.
    • To evaluate the impact of reducing SC compression on functional recovery and spasticity.

    Main Methods:

    • A simulation model of open penetrating spinal cord (SC) trauma was created in adult male Wistar rats.

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  • The model involved half transection of the SC cross-section with durable compression by a biocompatible foreign body.
  • Changes in spasticity, pain, and functional activity were monitored following compression and its reduction.

    • Main Results:

    • Foreign body compression of the injured SC potentiated spasticity syndrome formation.
    • SC compression did not significantly influence or restrict the occurrence of severe pain syndrome.
    • Reduction of SC compression correlated with improved functional activity and reduced spasticity in paretic extremities.
    • Changes in efferent chain activity occurred in both injured and intact SC parts, independent of the foreign body's presence.

    Conclusions:

    • Foreign body-induced compression exacerbates posttraumatic spasticity following SC trauma.
    • Alleviating SC compression can lead to functional recovery and spasticity reduction.
    • The development of spasticity involves changes in both injured and intact SC segments.