[IMPACT OF XENOTRANSPLANTATION OF NEUROGENIC STEM CELLS IN COMPLEX WITH THE TISSUE MATRIX NEUROGELTM ON RESTORATION...

Area of Science:

• Regenerative Medicine
• Neuroscience
• Biomaterials Engineering

Background:

• Spinal cord trauma (SCT) presents significant challenges in motor function restoration.
• Current treatments often lack sufficient neuroprotective and regenerative capabilities.

Purpose of the Study:

• To introduce and evaluate a novel restorative treatment for experimental SCT.
• To assess the efficacy of combining a synthetic matrix with neurogenic stem cells for spinal cord repair.

Main Methods:

• Experimental spinal cord trauma was induced in a model.
• A synthetic matrix (NeuroGelTM) was implanted in combination with neurogenic stem cells.
• Motor function of the posterior ipsilateral extremity (PIE) was assessed using the Basso–Beattie–Bresnahan (BBB) scale.

Main Results:

• The combined therapy demonstrated a significant enhancement in the early neuroprotective effects.
• A notable reduction in the time required for early restoration of PIE motor function was observed.
• The synthetic matrix, NeuroGelTM, played a crucial role in supporting cell integration and function.

Conclusions:

• The proposed method offers a promising therapeutic strategy for spinal cord trauma.
• Combining synthetic matrices with neurogenic stem cells can accelerate functional recovery post-SCT.
• This approach holds potential for improving neuroprotection and motor function rehabilitation.