Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

1.9K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.9K
Tumor Progression02:07

Tumor Progression

7.4K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.4K
The Tumor Microenvironment02:17

The Tumor Microenvironment

7.8K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.8K
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

6.0K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
6.0K
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

6.1K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
6.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-term outcomes of evolving treatment regimens in Ewing sarcoma survivors diagnosed 1970-1999: A report from the Childhood Cancer Survivor Study.

Cancer·2026
Same author

Current Challenges in Pediatric Hematology and Oncology: An Integrated Multidisciplinary Perspective.

European journal of haematology·2026
Same author

Bivalirudin use and Outcomes in Neonates With Congenital Diaphragmatic Hernia Managed With Extracorporeal Life Support.

Annals of surgery·2026
Same author

Indocyanine Green Fluorescence for Intraoperative Tumor Identification During Resection of Pediatric and Adolescent Intra-Abdominal Malignancy: A Prospective Multi-Institutional Observational Study.

Journal of the American College of Surgeons·2026
Same author

Purpuric Patches as Cutaneous Presentation of Pediatric NTRK-Rearranged Spindle Cell Neoplasm.

Pediatric dermatology·2026
Same author

Trisomy 21 and postoperative outcomes after esophageal atresia repair: A propensity score matching study.

Journal of pediatric surgery·2026
Same journal

Reimagining the Surgical Safety Checklist Through a Pediatric Lens.

Journal of pediatric surgery·2026
Same journal

Bridge Fixation Provides Consistent Implant Stability Across Surgical Techniques: A Multicenter Study.

Journal of pediatric surgery·2026
Same journal

National Benchmarks for Penetrating Head Injury in U.S. Children and Adolescents: Mechanism, Intent, and Disparities in Mortality.

Journal of pediatric surgery·2026
Same journal

Long-Term Growth and Neurodevelopmental Outcomes of a Standardized Gastroschisis Feeding Protocol: a retrospective cohort study.

Journal of pediatric surgery·2026
Same journal

Economic Evaluation of Hirschsprung Disease Testing Strategies for Children with Medically-Refractory Chronic Constipation: A Cost-Effectiveness Analysis.

Journal of pediatric surgery·2026
Same journal

Preoperative underweight is associated with a more complicated perioperative course and impairs recovery in Hirschsprung's disease: The pivotal role of weight-for-age z-score.

Journal of pediatric surgery·2026
See all related articles

Related Experiment Video

Updated: Feb 4, 2026

The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time
06:05

The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time

Published on: February 19, 2021

1.8K

Update on Wilms tumor.

Jennifer H Aldrink1, Todd E Heaton2, Roshni Dasgupta3

  • 1Department of Surgery, Division of Pediatric Surgery, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, OH.

Journal of Pediatric Surgery
|October 2, 2018
PubMed
Summary
This summary is machine-generated.

This review summarizes current Wilms tumor treatment standards for children, incorporating clinical trial data and surgical impacts on risk stratification. It highlights evidence-based approaches for optimal pediatric cancer care.

Keywords:
SurgeryWilms tumor

More Related Videos

Updated Protocol for the Assembly and Use of the Minibioreactor Array (MBRA)
09:38

Updated Protocol for the Assembly and Use of the Minibioreactor Array (MBRA)

Published on: September 5, 2025

900
Establishment of a Co-culture System of Patient-Derived Colorectal Tumor Organoids and Tumor-Infiltrating Lymphocytes (TILs)
08:42

Establishment of a Co-culture System of Patient-Derived Colorectal Tumor Organoids and Tumor-Infiltrating Lymphocytes (TILs)

Published on: June 27, 2025

2.3K

Related Experiment Videos

Last Updated: Feb 4, 2026

The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time
06:05

The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time

Published on: February 19, 2021

1.8K
Updated Protocol for the Assembly and Use of the Minibioreactor Array (MBRA)
09:38

Updated Protocol for the Assembly and Use of the Minibioreactor Array (MBRA)

Published on: September 5, 2025

900
Establishment of a Co-culture System of Patient-Derived Colorectal Tumor Organoids and Tumor-Infiltrating Lymphocytes (TILs)
08:42

Establishment of a Co-culture System of Patient-Derived Colorectal Tumor Organoids and Tumor-Infiltrating Lymphocytes (TILs)

Published on: June 27, 2025

2.3K

Area of Science:

  • Pediatric Oncology
  • Surgical Oncology
  • Evidence-Based Medicine

Background:

  • Wilms tumor is a common pediatric kidney cancer.
  • Established treatment protocols are crucial for improving patient outcomes.
  • Current evidence-based standards guide pediatric cancer management.

Purpose of the Study:

  • To review current evidence-based treatment standards for pediatric Wilms tumor.
  • To summarize recent clinical trials and diagnostic evaluations.
  • To highlight the role of surgical impact in risk stratification.

Main Methods:

  • Review of Level 1 studies from the Children's Oncology Group.
  • Inclusion of expert opinion (Level V) from the American Pediatric Surgical Association Cancer Committee.
  • Synthesis of diagnostic and surgical standards.

Main Results:

  • Summary of recently completed clinical trials.
  • Discussion of current diagnostic evaluation and surgical standards.
  • Highlight of surgical impact on Wilms tumor risk stratification.

Conclusions:

  • Current evidence-based standards provide a framework for Wilms tumor treatment.
  • Recent clinical trials inform evolving treatment strategies.
  • Surgical approaches significantly influence patient risk stratification and management.