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Updated: Sep 4, 2026

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas
Published on: September 13, 2019
Non-rhabdomyosarcoma Soft Tissue Sarcoma
Daniel S Rhee1, David A Rodeberg2
1Division of Pediatric Surgery, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Abstract:
Non-rhabdomyosarcoma soft tissue sarcomas (NRSTS) is a diverse group of soft tissue sarcomas with a wide range of behavior, presentation, and response to treatment. As most NRSTS are not responsive to chemotherapy, surgery remains the cornerstone of treatment and excellent outcomes for low-risk tumors can be achieved with surgery alone. The prognosis for high-risk, metastatic, or advanced tumors remains poor despite aggressive multi-modal treatment and new treatment modalities are needed. Studying NRSTS as a combined classification in cooperative group trials has been successful in identifying prognostic factors and optimizing treatment strategies for this diverse group of tumors.
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