[Patent foramen ovale closure in patients with apoplexia]

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Updated: Feb 4, 2026

Closure of a Patent Foramen Ovale PFO: An Intervention Sequence
10:52

Closure of a Patent Foramen Ovale PFO: An Intervention Sequence

Published on: December 23, 2022

5.9K

Anna Gundlund1, Niels Holmark Andersen, Morten Dalsgaard

  • 1annagundlund@gmail.com.

Ugeskrift for Laeger
|October 3, 2018
PubMed

Insights

Patent foramen ovale (PFO) closure reduces stroke recurrence in cryptogenic ischaemic stroke (CIS) patients. Evidence supports PFO closure over antithrombotic therapy alone for these individuals.

Area of Science:

  • Cardiology
  • Neurology
  • Medical Research

Background:

  • Patent foramen ovale (PFO) is more common in cryptogenic ischaemic stroke (CIS) patients.
  • Previous studies indicated a link between PFO and CIS.
  • The role of PFO closure in CIS management has been debated.

Purpose of the Study:

  • To review current evidence on PFO closure for CIS.
  • To analyze the efficacy of PFO closure versus antithrombotic therapy.
  • To propose future recommendations for PFO closure in CIS patients.

Main Methods:

  • Systematic review of randomized clinical trials.
  • Analysis of stroke recurrence rates.
  • Comparison of PFO closure versus antithrombotic therapy outcomes.

Main Results:

  • Three 2017 trials demonstrated a benefit of PFO closure in CIS.
  • PFO closure significantly lowered stroke recurrence risk compared to antithrombotic therapy alone.
  • Patients with CIS and PFO showed improved outcomes with closure.

Conclusions:

  • PFO closure is a beneficial therapeutic option for select CIS patients.
  • Evidence supports PFO closure over antithrombotic therapy for PFO-positive CIS.
  • Future guidelines should consider PFO closure in CIS management.

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