Related Experiment Video
Updated: Feb 4, 2026

Modeling Myotonic Dystrophy 1 in C2C12 Myoblast Cells
Published on: July 29, 2016
Stepping Activity in Children With Congenital Myotonic Dystrophy
Heather A Hayes1, Deanna Dibella, Rebecca Crockett
1Department of Physical Therapy and Athletic Training (Dr Hayes) and Department of Neurology (Mss Dibella and Crockett and Drs Dixon, Butterfield, and Johnson), University of Utah, Salt Lake City, Utah.
Purpose:
The purpose of this study was to investigate the physical activity levels in children with congenital myotonic dystrophy (CDM), and to examine whether patient clinical and functional characteristics correlated to physical activity.
Methods:
Twenty-five children with CDM were assessed on functional measures, clinical measures, and physical activity levels.
Results:
Results support that children with CDM spend the majority of their time inactive. There was a negative correlation between inactivity and cytosine-thymine-guanine repeats, suggesting increased inactivity with increased CDM severity. Age, body mass index, and lean muscle mass may be factors influencing activity levels.
Conclusions:
Children in this study received one-third the recommended steps per day. The number of steps per day is not correlated with clinical measures.
Related Concept Videos
Satellite Stem Cells and Muscular Dystrophy
Rate-Determining Steps
In a multistep reaction mechanism, one of the elementary steps progresses significantly slower than the others. This slowest step is called the rate-limiting step (or rate-determining step). A reaction cannot proceed faster than its slowest step, and hence, the rate-determining step limits the overall reaction rate.
The concept of rate-determining step can be understood from the analogy of a 4-lane freeway with a short-stretch of traffic-bottleneck caused due to...
Drug Dosing: Infants and Children
Regulation of Expression Occurs at Multiple Steps
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Steps in Outbreak Investigation
Steps in the Modeling Process
Attention is the first necessary component for observational learning. It involves focusing on what the model is doing and saying. For example, if you decide to take a drawing class to enhance your skills, you need to pay close attention to the instructor's words and hand movements. The characteristics of the model significantly...

