Related Experiment Videos
Syringocystadenoma papilliferum developed from giant comedo: a case report
Abstract:
A case of syringocystadenoma papilliferum in a 44-year-old Japanese male provided interesting clinical and histological findings. The lesion was diagnosed clinically as an infectious when on the flexor aspect of the right thigh. Optical microscopical examination of serial sections showed that the tumor parenchyma was deeply seated along the boundary zone between the cutis and subcutis around the lower half of a giant comedo, and extended into the surrounding tissues from the non-keratinized epithelial portion of the giant comedo where the non-keratinized epithelium merged with the upper, keratinized epithelium. The tumor thus appeared to have developed from the non-keratinized transitional epithelium corresponding to the intrafollicular part of the apocrine sweat gland apparatus. Although 103 cases of syringocystadenoma papilliferum have been reported from Japan since 1924, the present findings are both clinically and histologically unique.
Insights
This case report details a unique syringocystadenoma papilliferum in a Japanese male, presenting unusual clinical and histological features. The rare skin tumor appears to originate from the apocrine sweat gland apparatus.
Area of Science:
- Dermatopathology
- Oncology
Background:
- Syringocystadenoma papilliferum (SCAP) is a rare benign adnexal tumor.
- Previous reports of SCAP in Japan total 103 cases since 1924.
Observation:
- A 44-year-old Japanese male presented with a lesion initially misdiagnosed as infectious.
- Histological examination revealed the tumor parenchyma originating from the non-keratinized epithelium of a giant comedo.
- The tumor extended into surrounding tissues, merging with keratinized epithelium.
Findings:
- The SCAP demonstrated a unique origin from the transitional epithelium of the intrafollicular portion of the apocrine sweat gland apparatus.
- The tumor's deep-seated location at the cutis-subcutis junction was notable.
- Clinical presentation mimicked an infectious process.
Implications:
- This case expands the understanding of SCAP histogenesis and its potential origins.
- Highlights the importance of thorough histological examination for accurate diagnosis of adnexal tumors.
- Contributes to the literature on rare skin neoplasms in the Japanese population.