Related Experiment Video
Updated: Feb 4, 2026
05:39
Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
Published on: May 16, 2025
668
Diet Quality and High-Sensitivity C-Reactive Protein in Patients With Systemic Lupus Erythematosus
G Pocovi-Gerardino1,2, M Correa-Rodríguez1,3, J-L Callejas Rubio1,4
11 Instituto de Investigación Biosanitaria (IBS), Granada, Spain.
Biological Research for Nursing
|October 5, 2018
Summary
Systemic lupus erythematosus (SLE) patients often have low-quality diets. This study found no link between diet quality, nutrient intake, and C-reactive protein (CRP) levels in SLE patients, suggesting diet may not impact inflammation markers in this group.
Area of Science:
- Rheumatology
- Nutrition Science
- Clinical Biomarkers
Background:
- C-reactive protein (CRP) is a key inflammation biomarker, with mild elevations seen in systemic lupus erythematosus (SLE).
- CRP is associated with increased cardiovascular event risk in SLE patients.
- Diet quality influences CRP in healthy individuals, but its role in SLE remains unstudied.
Purpose of the Study:
- To investigate the relationship between dietary nutrient intake, antioxidant consumption, and serum CRP levels in SLE patients.
- To determine if diet quality affects inflammatory status in SLE.
Main Methods:
- Cross-sectional study of 91 SLE patients.
- Serum high-sensitivity CRP (hsCRP) measured via immunoassay.
- Dietary intake assessed using 24-hour recalls and the Dietary Antioxidant Quality score (DAQs).
- Linear regression models analyzed associations between diet and hsCRP.
Main Results:
- Mean hsCRP levels were elevated (3.76 ± 6.68 mg/L) in the SLE cohort.
- Patients exhibited low-quality diets.
- No significant correlations were found between macro/micronutrient intake, DAQs, and serum hsCRP levels.
Conclusions:
- SLE patients in this study consumed low-quality diets that did not correlate with serum CRP levels.
- Further interventional studies are needed to clarify the role of high-quality diets on CRP in SLE.
Related Concept Videos
01:29Protein Folding Quality Check in the RER
5.3K
ER is the primary site for the maturation and folding of soluble and transmembrane secretory proteins. The calnexin cycle is a specific chaperone system that folds and assesses the confirmation of N-glycosylated proteins before they can exit the ER lumen. The primary players of this quality check pipeline are the lectins, ER-resident chaperones, and a glucosyl transferase enzyme. In case the calnexin system in the lumen fails to salvage a misfolded protein, it is transported to the cytoplasm...
5.3K
01:17Gram-negative Bacterial Protein Secretion Systems
945
Gram-negative bacteria utilize sophisticated protein secretion systems to transport proteins across their double-membrane envelope into the extracellular environment or host cells. Based on their mechanism of action, these systems are classified into one-step and two-step pathways.One-Step Secretion Systems (Types I, III, IV, and VI)One-step secretion systems bypass the periplasm entirely, forming a continuous channel that spans both the inner and outer membranes:Type I Secretion System (T1SS):...
945
00:42Cross-reactivity
33.1K
Overview
33.1K
01:18Reactivity of Enols
4.1K
Enols are a class of compounds where a hydroxyl group is attached to a carbon–carbon double bond, which implies that it is a vinyl alcohol. A carbonyl compound with an α hydrogen undergoes keto–enol tautomerism and remains in equilibrium with its tautomer, the enol form. Usually, the keto tautomer is present in a higher concentration than the enol tautomer due to the higher bond energy of C=O compared to C=C. Moreover, the direction of the keto–enol equilibrium is...
4.1K
01:05Quality Control
2.6K
Quality control is one of the three cyclical quality assurance activities that help keep a system under statistical control. Typical quality control activities include creating quality control charts, conducting proficiency testing, and documenting and archiving results.
Quality control helps track data, visualize trends, and identify variations, making it easier to detect deviations that may affect the accuracy of an analysis. One way to do this is by generating a quality control chart, which...
Quality control helps track data, visualize trends, and identify variations, making it easier to detect deviations that may affect the accuracy of an analysis. One way to do this is by generating a quality control chart, which...
2.6K
01:19Quality Assurance
2.3K
Quality assurance is the overarching term used to describe the activities employed to ensure the proper performance of a system. These activities can be classified into three categories: quality control, quality assessment, and internal corrective measures. Typically, these activities work cyclically: quality control is performed before and during the analysis, while quality assessment occurs during and after the investigation. Internal corrective measures are implemented based on the findings...
2.3K