Related Experiment Video
Updated: Feb 4, 2026

Brain Banking: Making the Most of your Research Specimens
Published on: July 24, 2009
Utility of chloroquine diphosphate in the blood bank laboratory
Thandar Aye1, Patricia A Arndt2
1Senior Technologist, Immunohematology Reference Laboratory, Bloodworks NW.
Conclusions:
Chloroquine diphosphate (CDP) is a helpful tool in the blood bank for two main applications. The most common application is to render direct antiglobulin test-positive red blood cells (RBCs) free from membrane-bound IgG; these treated RBCs can then be used for autologous adsorption and/or to determine the patient's RBC phenotype. Another common use of CDP is to remove human leukocyte antigens (HLAs) from RBCs to help identify or exclude the presence of antibodies to HLAs expressed on RBCs, for example, Bennett-Goodspeed (Bg) antigens. In this review, the principles, applications, and limitations of using CDP are discussed.
Related Concept Videos
Serum Laboratory Studies, Stool Test, Breath Test
Composition of Blood
Formed elements constitute the remaining 45% of the blood volume. These...
Blood Flow
Blood Types
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
Blood Pressure
Blood Pressure
The average BP in an adult is typically around 120/80 mmHg (millimeters of mercury). In this measurement, the numerator (120) indicates the systolic pressure, which is the pressure in the arteries during the contraction of the heart's ventricles as blood is expelled. The denominator (80) represents the...

