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Central Obesity, Faster Maturation, and 'PCOS' in Girls
Francis de Zegher1, Abel López-Bermejo2, Lourdes Ibáñez3
1Pediatric Endocrinology, University of Leuven, Leuven, Belgium.
Trends in Endocrinology and Metabolism: TEM
|October 10, 2018
Abstract:
Polycystic ovary syndrome (PCOS) development commonly starts with a mismatch between pre- and postnatal weight gain, leading to hepatovisceral fat excess. To escape from such central obesity, girls may accelerate their growth and/or maturation. This homeostatic mechanism is lost upon reaching adult height, and PCOS may ensue. Prevention and/or treatment of PCOS should aim at reducing central fat excess.