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Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
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18F-DCFPyL PET/CT in Oncocytoma
Jeremy Li, Richard Xu, Chun K Kim1
1Hanyang University College of Medicine, Seoul, South Korea.
Clinical Nuclear Medicine
|October 10, 2018
Summary
F-DCFPyL PET/CT imaging detected prostate cancer recurrence and an unexpected kidney oncocytoma. This highlights the utility of PSMA-targeted imaging in identifying both primary cancer sites and incidental findings.
Area of Science:
- Oncology
- Nuclear Medicine
- Radiology
Background:
- Prostate cancer recurrence after radiotherapy poses diagnostic challenges.
- Prostate-specific membrane antigen (PSMA) is a key biomarker overexpressed in prostate cancer.
- Novel imaging agents targeting PSMA offer improved detection capabilities.
Observation:
- A 76-year-old man with biochemical failure post-radiotherapy showed no disease on conventional imaging.
- F-DCFPyL PET/CT, a PSMA-targeted imaging agent, revealed lymph node metastases.
- The scan also identified photopenic defects in the left kidney, later diagnosed as oncocytoma.
Findings:
- PSMA-targeted F-DCFPyL PET/CT successfully identified recurrent prostate cancer.
- The imaging revealed an incidental finding of biopsy-proven oncocytoma in the kidney.
- PSMA expression was noted in the oncocytoma, consistent with its presence in tumor neovasculature.
Implications:
- PSMA-targeted PET/CT is valuable for detecting prostate cancer recurrence and staging.
- This imaging modality can identify unexpected non-prostate cancer findings, such as renal oncocytoma.
- Biopsy confirmation remains crucial for all F-DCFPyL avid lesions, irrespective of suspected pathology.
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