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Updated: Feb 4, 2026

Dissection of Imaginal Discs from 3rd Instar Drosophila Larvae
Published on: February 17, 2007
Modulation of neuromuscular synapses and contraction in Drosophila 3rd instar larvae
Kiel G Ormerod1, JaeHwan Jung2, A Joffre Mercier2
1a Department of Biology , Massachusetts Institute of Technology , Cambridge , MA , USA.
Abstract:
Over the past four decades, Drosophila melanogaster has become an increasingly important model system for studying the modulation of chemical synapses and muscle contraction by cotransmitters and neurohormones. This review describes how advantages provided by Drosophila have been utilized to investigate synaptic modulation, and it discusses key findings from investigations of cotransmitters and neurohormones that act on body wall muscles of 3rd instar Drosophila larvae. These studies have contributed much to our understanding of how neuromuscular systems are modulated by neuropeptides and biogenic amines, but there are still gaps in relating these peripheral modulatory effects to behavior.
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