Erythema exsudativum multiforme (EEM) is a sudden inflammation of the skin and/or mucous membranes (minor or major form). It typically affects healthy, young, male adults. The lips are affected first or sometimes exclusively. The buccal mucosa, the buccal gingiva and the tongue can also be affected. Less frequently, intraoral lesions are also found on the hard and soft palate and the floor of the mouth. Patients report severe pain when eating, swallowing and speaking. The clinical picture is usually sufficient diagnostic evidence and no histopathological examination is required.