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Non-Invasive Ultrasound Assessment of Endometrial Cancer Progression in Pax8-Directed Deletion of the Tumor Suppressors Arid1a and Pten in Mice
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Linking Autophagy and the Dysregulated NFκB/ SNAIL/YY1/RKIP/PTEN Loop in Cancer: Therapeutic Implications

Benjamin Bonavida1

  • 1Department of Microbiology, Immunology, & Molecular Genetics, David Geffen School of Medicine, Johnson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA 90025-1747.

Critical Reviews in Oncogenesis
|October 13, 2018
PubMed

Insights

Autophagy regulates cancer cell behaviors and treatment responses. This review details the link between autophagy and a key cancer-associated gene circuit, revealing crosstalk with therapeutic implications.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • Autophagy is crucial in cancer pathogenesis, influencing proliferation, metastasis, and treatment response.
  • A specific dysregulated gene circuit (NFκB/SNAIL/YY1/RKIP/PTEN) is implicated in regulating cancer cell characteristics.
  • Similarities in function suggest a molecular link between autophagy and this gene circuit.

Purpose of the Study:

  • To elucidate the biochemical/molecular link between autophagy and the dysregulated NFκB/SNAIL/YY1/RKIP/PTEN circuit in cancer.
  • To describe the association of each gene product within the circuit to autophagic mechanisms.
  • To highlight the crosstalk between autophagy and the circuit and its therapeutic relevance.

Main Methods:

  • Review of existing literature on autophagy in cancer.
  • Analysis of gene products within the NFκB/SNAIL/YY1/RKIP/PTEN circuit.
  • Examination of molecular and biochemical mechanisms governing autophagy and the circuit.

Main Results:

  • Detailed description of the link between autophagy and the dysregulated gene circuit.
  • Identification of crosstalk between autophagic mechanisms and the circuit's gene products.
  • Demonstration that both autophagy and the circuit influence cancer cell proliferation, viability, invasion, EMT, metastasis, and treatment responses.

Conclusions:

  • Significant crosstalk exists between autophagy and the NFκB/SNAIL/YY1/RKIP/PTEN circuit in cancer cells.
  • This crosstalk has critical implications for developing targeted cancer therapies.
  • Targeting either autophagy or specific gene products in the circuit offers potential therapeutic strategies.

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