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Updated: Feb 4, 2026
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Laser-heating and Radiance Spectrometry for the Study of Nuclear Materials in Conditions Simulating a Nuclear Power Plant Accident
Published on: December 14, 2017
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Open-Label Study of the Stability of Sublingual Nitroglycerin Tablets in Simulated Real-Life Conditions
James J Nawarskas1, Jason Koury2, David A Lauber1
1University of New Mexico College of Pharmacy, Albuquerque, New Mexico.
The American Journal of Cardiology
|October 14, 2018
Summary
Sublingual nitroglycerin (SL NTG) stability varies with storage and carrying habits. Refill frequency for this heart medication should be individualized based on patient behavior, not outdated guidelines.
Area of Science:
- Pharmacology
- Pharmaceutical Science
Background:
- Current recommendations for sublingual nitroglycerin (SL NTG) refills every 3-6 months are based on outdated data.
- These recommendations do not account for reformulated SL NTG tablets or improved manufacturing processes.
Purpose of the Study:
- To investigate the chemical and physical stability of SL NTG over time.
- To compare SL NTG stability under simulated real-life conditions versus controlled storage.
Main Methods:
- An open-label study involving 100- and 25-count SL NTG bottles.
- Tablets were stored under controlled conditions or carried in pockets/purses.
- Potency was assessed via high-performance liquid chromatography; physical stability by tablet weight changes.
Main Results:
- High temperatures accelerated SL NTG potency loss.
- Tablets carried in pant pockets lost potency faster than those in purses.
- Potency retention depended on bottle headspace and carrying method; 25-count bottles in pant pockets maintained potency for 2 years, while 100-count bottles did not.
Conclusions:
- SL NTG stability is influenced by temperature, headspace, and patient carrying practices.
- Individual patient behavior should guide SL NTG refill frequency, moving beyond standardized intervals.
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