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Expression of Transgenes in Native Bladder Urothelium Using Adenovirus-Mediated Transduction
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Neuropathic Bladder and Augmentation Cystoplasty.

Joshua D Roth1, Mark P Cain1

  • 1Department of Pediatric Urology, 705 Riley Hospital Drive, Suite 4230, Indianapolis, IN 46202, USA.

The Urologic Clinics of North America
|October 15, 2018
PubMed
Summary
This summary is machine-generated.

Neuropathic bladder management involves surgery for severe cases unresponsive to other treatments. Bladder augmentation is a common surgery, but carries significant long-term risks.

Keywords:
Augmentation cystoplastyNeurogenic bladderNeuropathic bladder

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Area of Science:

  • Urology
  • Nephrology

Background:

  • Neuropathic bladder presents challenges in urinary storage and upper tract protection.
  • Current treatments include pharmacologic therapy, injections, and intermittent catheterization.

Purpose of the Study:

  • To review the surgical indications for neuropathic bladder.
  • To discuss the management of neuropathic bladder, including bladder augmentation.
  • To examine the long-term consequences of bladder augmentation.

Main Methods:

  • Literature review of medical and surgical management of neuropathic bladder.
  • Analysis of surgical indications and outcomes.
  • Review of long-term risks associated with bladder augmentation.

Main Results:

  • Surgical indications include unsafe storage pressures, upper tract deterioration, and refractory incontinence.
  • Bladder augmentation is the gold standard for increasing capacity and reducing pressures.
  • Bladder augmentation has significant long-term risks.

Conclusions:

  • Surgical intervention is reserved for refractory neuropathic bladder cases.
  • Bladder augmentation is effective but requires careful consideration of long-term risks.
  • Comprehensive management strategies are essential for patients with neuropathic bladder.