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Ciliary muscle thickness profiles derived from optical coherence tomography images
Sandra Wagner1, Eberhart Zrenner1,2, Torsten Strasser1
1Institute for Ophthalmic Research, Eberhard Karls University Tuebingen, Elfriede-Aulhorn-Str. 7, 72076 Tuebingen, Germany.
Biomedical Optics Express
|October 16, 2018
Summary
The ciliary muscle (CM) thins in its anterior part and thickens in its posterior part during accommodation, offering a detailed view of these morphological changes. This study quantifies accommodative shifts across the entire CM boundary.
Area of Science:
- Ophthalmology
- Biomechanics
- Anatomy
Background:
- Accommodation is crucial for clear vision, involving ciliary muscle (CM) contraction.
- Previous studies on CM morphology during accommodation have limitations in resolution and scope.
- Understanding CM shape changes is key to explaining visual function and dysfunction.
Purpose of the Study:
- To analyze ciliary muscle (CM) morphological changes during accommodation.
- To evaluate ciliary muscle thickness (CMT) profiles with high precision.
- To quantify accommodative changes across the entire CM boundary.
Main Methods:
- Used optical coherence tomography (OCT) to image the CM in 15 subjects (age 20-39) during far (0 D) and near (3 D) vision.
- Developed a Java-based program for semi-automatic CM segmentation and thickness measurements.
- Generated detailed CMT profiles for precise analysis of shape alterations.
Main Results:
- Observed average CM thinning within the anterior 0.25 mm.
- Detected average CM thickening from 0.36 mm to 1.48 mm posterior to the scleral spur.
- Quantified regional thickness changes during a 3 D accommodative stimulus.
Conclusions:
- The study provides a pixel-wise reconstruction of CM shape changes during accommodation.
- This method offers a more comprehensive quantification of accommodative shifts compared to prior analyses.
- Findings enhance understanding of ciliary muscle biomechanics during the accommodation process.
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