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[Antithrombotic therapy in patients with peripheral artery diseases]

A V Svetlikov1, S V Sapelkin2, L É Ishpulaeva3

  • 1Clinical Hospital No122 named after L.G. Sokolov under the Federal Biomedical Agency of the Russian Federation, Saint Petersburg, Russia; North-Western State Medical University named after I.I. Mechnikov under the RF Ministry of Public Health, Saint Petersburg, Russia.

Angiologiia I Sosudistaia Khirurgiia = Angiology and Vascular Surgery
|October 16, 2018
PubMed

Insights

Atherothrombosis complications, including peripheral artery disease (PAD), are leading causes of death. Current antithrombotic therapies like aspirin are standard for PAD, but optimizing treatment after revascularization remains challenging.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Surgery
  • Thrombosis Research

Background:

  • Atherothrombosis is a primary driver of cardiovascular disease mortality globally.
  • Peripheral artery disease (PAD) significantly worsens patient prognosis and increases mortality risk.
  • Optimizing antithrombotic therapy is crucial for managing ischemic complications in cardiovascular patients.

Purpose of the Study:

  • To review current antithrombotic therapy strategies for peripheral artery disease (PAD).
  • To evaluate the effectiveness of acetylsalicylic acid as a standard treatment for PAD.
  • To address the complexities of selecting antithrombotic therapy post-revascularization in PAD patients.

Main Methods:

  • Literature review of antithrombotic therapies for PAD over the past two decades.
  • Analysis of treatment guidelines and clinical trial data for acetylsalicylic acid.
  • Examination of challenges and emerging strategies for antithrombotic therapy post-revascularization.

Main Results:

  • Acetylsalicylic acid remains the established standard antithrombotic therapy for PAD.
  • Despite its use, ischemic complications persist as a significant concern in PAD patients.
  • Selecting optimal antithrombotic regimens after revascularization presents ongoing clinical challenges.

Conclusions:

  • Current antithrombotic strategies, while including aspirin, necessitate further refinement for PAD.
  • Improved antithrombotic approaches are needed to reduce ischemic events, particularly after revascularization.
  • Further research is essential to personalize and enhance antithrombotic therapy in cardiovascular disease management.

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